|
KMID : 1100220070060020029
|
|
Dementia and Neurocognitive Disorders
2007 Volume.6 No. 2 p.29 ~ p.33
|
|
|
Regional Cerebral Blood Flow Patterns in Amnestic Mild Cognitive Impairment and Early Alzheimer’s Disease
|
|
Shim Yong-Soo
Yang Dong-Won
Kim Beum-Saeng
Chung Yong-An
|
|
|
Abstract
|
|
|
Background: Amnestic mild cognitive impairment (aMCI) is an intermediary state between normal aging and Alzheimer’s disease (AD). Previous studies have shown that most of the aMCI patients have histopathologic changes compatible with AD. We studied patterns of regional cerebral blood flow (rCBF) in aMCI and early AD with statistical parametric mapping (SPM) analysis of 99mTc-ECD single photon emission computed tomography (SPECT) to estimate the functional abnormality in two groups.
Methods: Eighteen subjects with early AD (male 7, female 11, age 69.60±76.78) and 16 subjects with aMCI (male 6, female 10, age 69.19±7.13) were recruited. ECD-SPECT was performed in two groups and 14 age-matched normal controls, and SPM analysis was conducted to identify brain regions with decreased rCBF in each groups.
Results: Significantly decreased rCBF was observed in the left inferior temporal, thalamus, superior temporal, and bilateral prefrontal and parietal areas in the aMCI group as compared to normal controls. In the early AD group, similar patterns of decreased rCBF were observed. The early AD group had greater decreased rCBF in the left superior prefrontal area as compared to the aMCI group.
Conclusions: Although aMCI is an intermediary state between normal aging and AD, cerebral function measured by rCBF in aMCI was already decreased to a similar extent of that observed in early AD. The early AD group had a greater decreased rCBF in the superior prefrontal area, which is probably associated with impairment in the activities of daily living.
|
|
|
KEYWORD
|
|
|
Mild cognitive impairment, Alzheimer’s disease, SPECT, Statistical parametric mapping
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
 
|
|